Centrosome amplification induced by DNA damage occurs during a prolonged G2 phase and involves ATM

Centrosomes are the principal microtubule organising centres in somatic cells. Abnormal centrosome number is common in tumours and occurs after γ-irradiation and in cells with mutations in DNA repair genes. To investigate how DNA damage causes centrosome amplification, we examined cells that conditi...

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Autores principales: Dodson, Helen, Bourke, Emer, Jeffers, Liam J, Vagnarelli, Paola, Sonoda, Eiichiro, Takeda, Shunichi, Earnshaw, William C, Merdes, Andreas, Morrison, Ciaran
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2004
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC522792/
https://ncbi.nlm.nih.gov/pubmed/15359281
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600393
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