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A Centrosome-autonomous Signal That Involves Centriole Disengagement Permits Centrosome Duplication in G2 Phase after DNA Damage

DNA damage can induce centrosome overduplication in a manner that requires G2-to-M checkpoint function, suggesting that genotoxic stress can decouple the centrosome and chromosome cycles. How this happens is unclear. Using live-cell imaging of cells that express fluorescently tagged NEDD1/GCP-WD and...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Inanç, Burcu, Dodson, Helen, Morrison, Ciaran G.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: The American Society for Cell Biology 2010
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2982117/
https://ncbi.nlm.nih.gov/pubmed/20861312
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E10-02-0124
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