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DNA damage induces Chk1-dependent centrosome amplification
Centrosomal abnormalities are frequently observed in cancers and in cells with defective DNA repair. Here, we used light and electron microscopy to show that DNA damage induces centrosome amplification, not fragmentation, in human cells. Caffeine abrogated this amplification in both ATM (ataxia tela...
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| 主要な著者: | , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2007
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2002539/ https://ncbi.nlm.nih.gov/pubmed/17468739 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.embor.7400962 |
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