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The controlling role of ATM in homologous recombinational repair of DNA damage
The human genetic disorder ataxia telangiectasia (A–T), caused by mutation in the ATM gene, is characterized by chromosomal instability, radiosensitivity and defective cell cycle checkpoint activation. DNA double-strand breaks (dsbs) persist in A–T cells after irradiation, but the underlying defect...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Oxford University Press
2000
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC305583/ https://ncbi.nlm.nih.gov/pubmed/10654944 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/19.3.463 |
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