The controlling role of ATM in homologous recombinational repair of DNA damage

The human genetic disorder ataxia telangiectasia (A–T), caused by mutation in the ATM gene, is characterized by chromosomal instability, radiosensitivity and defective cell cycle checkpoint activation. DNA double-strand breaks (dsbs) persist in A–T cells after irradiation, but the underlying defect...

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Bibliographic Details
Main Authors: Morrison, Ciaran, Sonoda, Eiichiro, Takao, Noriaki, Shinohara, Akira, Yamamoto, Ken-ichi, Takeda, Shunichi
Format: Artigo
Language:Inglês
Published: Oxford University Press 2000
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Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC305583/
https://ncbi.nlm.nih.gov/pubmed/10654944
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/19.3.463
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