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Enhancing the pharmaceutical properties of protein drugs by ancestral sequence reconstruction
Optimization of a protein’s pharmaceutical properties is usually carried out by rational design and/or directed evolution. Here we test an alternative approach based on ancestral sequence reconstruction. Using available genomic sequence data on coagulation factor VIII and predictive models of molecu...
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| 出版年: | Nat Biotechnol |
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| 主要な著者: | , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2016
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5225049/ https://ncbi.nlm.nih.gov/pubmed/27669166 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nbt.3677 |
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