Nerve growth factor promotes gastric tumorigenesis through aberrant cholinergic signaling

Within the gastrointestinal stem cell niche, nerves help to regulate both normal and neoplastic stem cell dynamics. Here, we reveal the mechanisms underlying the cancer-nerve partnership. We find that Dclk1(+) tuft cells and nerves are the main sources of acetylcholine (ACh) within the gastric mucos...

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Pubblicato in:Cancer Cell
Autori principali: Hayakawa, Yoku, Sakitani, Kosuke, Konishi, Mitsuru, Asfaha, Samuel, Niikura, Ryota, Tomita, Hiroyuki, Renz, Bernhard W., Tailor, Yagnesh, Macchini, Marina, Middelhoff, Moritz, Jiang, Zhengyu, Tanaka, Takayuki, Dubeykovskaya, Zinaida A., Kim, Woosook, Chen, Xiaowei, Urbanska, Aleksandra M., Nagar, Karan, Westphalen, Christoph B., Quante, Michael, Lin, Chyuan-Sheng, Gershon, Michael D., Hara, Akira, Zhao, Chun-Mei, Chen, Duan, Worthley, Daniel L., Koike, Kazuhiko, Wang, Timothy C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5225031/
https://ncbi.nlm.nih.gov/pubmed/27989802
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2016.11.005
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