Nerve growth factor promotes gastric tumorigenesis through aberrant cholinergic signaling

Within the gastrointestinal stem cell niche, nerves help to regulate both normal and neoplastic stem cell dynamics. Here, we reveal the mechanisms underlying the cancer-nerve partnership. We find that Dclk1(+) tuft cells and nerves are the main sources of acetylcholine (ACh) within the gastric mucos...

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Bibliografske podrobnosti
izdano v:Cancer Cell
Main Authors: Hayakawa, Yoku, Sakitani, Kosuke, Konishi, Mitsuru, Asfaha, Samuel, Niikura, Ryota, Tomita, Hiroyuki, Renz, Bernhard W., Tailor, Yagnesh, Macchini, Marina, Middelhoff, Moritz, Jiang, Zhengyu, Tanaka, Takayuki, Dubeykovskaya, Zinaida A., Kim, Woosook, Chen, Xiaowei, Urbanska, Aleksandra M., Nagar, Karan, Westphalen, Christoph B., Quante, Michael, Lin, Chyuan-Sheng, Gershon, Michael D., Hara, Akira, Zhao, Chun-Mei, Chen, Duan, Worthley, Daniel L., Koike, Kazuhiko, Wang, Timothy C.
Format: Artigo
Jezik:Inglês
Izdano: 2016
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5225031/
https://ncbi.nlm.nih.gov/pubmed/27989802
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2016.11.005
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