Nerve growth factor promotes gastric tumorigenesis through aberrant cholinergic signaling

Within the gastrointestinal stem cell niche, nerves help to regulate both normal and neoplastic stem cell dynamics. Here, we reveal the mechanisms underlying the cancer-nerve partnership. We find that Dclk1(+) tuft cells and nerves are the main sources of acetylcholine (ACh) within the gastric mucos...

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Bibliografiska uppgifter
I publikationen:Cancer Cell
Huvudupphovsmän: Hayakawa, Yoku, Sakitani, Kosuke, Konishi, Mitsuru, Asfaha, Samuel, Niikura, Ryota, Tomita, Hiroyuki, Renz, Bernhard W., Tailor, Yagnesh, Macchini, Marina, Middelhoff, Moritz, Jiang, Zhengyu, Tanaka, Takayuki, Dubeykovskaya, Zinaida A., Kim, Woosook, Chen, Xiaowei, Urbanska, Aleksandra M., Nagar, Karan, Westphalen, Christoph B., Quante, Michael, Lin, Chyuan-Sheng, Gershon, Michael D., Hara, Akira, Zhao, Chun-Mei, Chen, Duan, Worthley, Daniel L., Koike, Kazuhiko, Wang, Timothy C.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2016
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5225031/
https://ncbi.nlm.nih.gov/pubmed/27989802
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2016.11.005
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