BHLHA15-positive Secretory Precursor Cells Can Give Rise to Tumors in Intestine and Colon in Mice

BACKGROUND & AIMS: The intestinal epithelium is maintained by long-lived intestinal stem cells (ISCs) that reside near the crypt base. Above the ISC zone, there are short-lived progenitors that normally give rise to lineage-specific differentiated cell types but can dedifferentiate into ISCs in...

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Pubblicato in:Gastroenterology
Autori principali: Hayakawa, Yoku, Tsuboi, Mayo, Asfaha, Samuel, Kinoshita, Hiroto, Niikura, Ryota, Konishi, Mitsuru, Hata, Masahiro, Oya, Yukiko, Kim, Woosook, Middelhoff, Moritz, Hikiba, Yohko, Higashijima, Naoko, Ihara, Sozaburo, Ushiku, Tetsuo, Fukayama, Masashi, Tailor, Yagnesh, Hirata, Yoshihiro, Guha, Chandan, Yan, Kelley S., Koike, Kazuhiko, Wang, Timothy C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6409180/
https://ncbi.nlm.nih.gov/pubmed/30448068
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2018.11.024
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