Neural innervation stimulates splenic TFF2 to arrest myeloid cell expansion and cancer

CD11b(+)Gr-1(+) myeloid-derived suppressor cells (MDSCs) expand in the spleen during cancer and promote progression through suppression of cytotoxic T cells. An anti-inflammatory reflex arc involving the vagus nerve and memory T cells is necessary for resolution of acute inflammation. Failure of thi...

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Bibliographic Details
Published in:Nat Commun
Main Authors: Dubeykovskaya, Zina, Si, Yiling, Chen, Xiaowei, Worthley, Daniel L., Renz, Bernhard W., Urbanska, Aleksandra M., Hayakawa, Yoku, Xu, Ting, Westphalen, C. Benedikt, Dubeykovskiy, Alexander, Chen, Duan, Friedman, Richard A., Asfaha, Samuel, Nagar, Karan, Tailor, Yagnesh, Muthupalani, Sureshkumar, Fox, James G., Kitajewski, Jan, Wang, Timothy C.
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2016
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4742920/
https://ncbi.nlm.nih.gov/pubmed/26841680
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms10517
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