Neural innervation stimulates splenic TFF2 to arrest myeloid cell expansion and cancer

CD11b(+)Gr-1(+) myeloid-derived suppressor cells (MDSCs) expand in the spleen during cancer and promote progression through suppression of cytotoxic T cells. An anti-inflammatory reflex arc involving the vagus nerve and memory T cells is necessary for resolution of acute inflammation. Failure of thi...

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Veröffentlicht in:Nat Commun
Hauptverfasser: Dubeykovskaya, Zina, Si, Yiling, Chen, Xiaowei, Worthley, Daniel L., Renz, Bernhard W., Urbanska, Aleksandra M., Hayakawa, Yoku, Xu, Ting, Westphalen, C. Benedikt, Dubeykovskiy, Alexander, Chen, Duan, Friedman, Richard A., Asfaha, Samuel, Nagar, Karan, Tailor, Yagnesh, Muthupalani, Sureshkumar, Fox, James G., Kitajewski, Jan, Wang, Timothy C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4742920/
https://ncbi.nlm.nih.gov/pubmed/26841680
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms10517
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