Through-bond effects in the ternary complexes of thrombin sandwiched by two DNA aptamers

Aptamers directed against human thrombin can selectively bind to two different exosites on the protein surface. The simultaneous use of two DNA aptamers, HD1 and HD22, directed to exosite I and exosite II respectively, is a very powerful approach to exploit their combined affinity. Indeed, strategie...

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Bibliografiske detaljer
Udgivet i:Nucleic Acids Res
Main Authors: Pica, Andrea, Russo Krauss, Irene, Parente, Valeria, Tateishi-Karimata, Hisae, Nagatoishi, Satoru, Tsumoto, Kouhei, Sugimoto, Naoki, Sica, Filomena
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2017
Fag:
Structural Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5224481/
https://ncbi.nlm.nih.gov/pubmed/27899589
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw1113
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