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B cell antigen extraction is regulated by physical properties of antigen-presenting cells

Antibody production and affinity maturation are driven by B cell extraction and internalization of antigen from immune synapses. However, the extraction mechanism remains poorly understood. Here we develop DNA-based nanosensors to interrogate two previously proposed mechanisms, enzymatic liberation...

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Detalhes bibliográficos
Publicado no:J Cell Biol
Main Authors: Spillane, Katelyn M., Tolar, Pavel
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5223605/
https://ncbi.nlm.nih.gov/pubmed/27923880
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201607064
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