Accumulation of Ubiquitin and Sequestosome-1 Implicate Protein Damage in Diacetyl-Induced Cytotoxicity

Inhaled diacetyl vapors are associated with flavorings-related lung disease, a potentially fatal airway disease. The reactive α-dicarbonyl group in diacetyl causes protein damage in vitro. Dicarbonyl/l-xylulose reductase (DCXR) metabolizes diacetyl into acetoin, which lacks this α-dicarbonyl group....

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Pubblicato in:Am J Pathol
Autori principali: Hubbs, Ann F., Fluharty, Kara L., Edwards, Rebekah J., Barnabei, Jamie L., Grantham, John T., Palmer, Scott M., Kelly, Francine, Sargent, Linda M., Reynolds, Steven H., Mercer, Robert R., Goravanahally, Madhusudan P., Kashon, Michael L., Honaker, John C., Jackson, Mark C., Cumpston, Amy M., Goldsmith, William T., McKinney, Walter, Fedan, Jeffrey S., Battelli, Lori A., Munro, Tiffany, Bucklew-Moyers, Winnie, McKinstry, Kimberly, Schwegler-Berry, Diane, Friend, Sherri, Knepp, Alycia K., Smith, Samantha L., Sriram, Krishnan
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Investigative Pathology 2016
Soggetti:
Regular Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5222965/
https://ncbi.nlm.nih.gov/pubmed/27643531
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2016.07.018
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