Accumulation of Ubiquitin and Sequestosome-1 Implicate Protein Damage in Diacetyl-Induced Cytotoxicity

Inhaled diacetyl vapors are associated with flavorings-related lung disease, a potentially fatal airway disease. The reactive α-dicarbonyl group in diacetyl causes protein damage in vitro. Dicarbonyl/l-xylulose reductase (DCXR) metabolizes diacetyl into acetoin, which lacks this α-dicarbonyl group....

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Udgivet i:Am J Pathol
Main Authors: Hubbs, Ann F., Fluharty, Kara L., Edwards, Rebekah J., Barnabei, Jamie L., Grantham, John T., Palmer, Scott M., Kelly, Francine, Sargent, Linda M., Reynolds, Steven H., Mercer, Robert R., Goravanahally, Madhusudan P., Kashon, Michael L., Honaker, John C., Jackson, Mark C., Cumpston, Amy M., Goldsmith, William T., McKinney, Walter, Fedan, Jeffrey S., Battelli, Lori A., Munro, Tiffany, Bucklew-Moyers, Winnie, McKinstry, Kimberly, Schwegler-Berry, Diane, Friend, Sherri, Knepp, Alycia K., Smith, Samantha L., Sriram, Krishnan
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Investigative Pathology 2016
Fag:
Regular Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5222965/
https://ncbi.nlm.nih.gov/pubmed/27643531
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2016.07.018
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