Accumulation of Ubiquitin and Sequestosome-1 Implicate Protein Damage in Diacetyl-Induced Cytotoxicity

Inhaled diacetyl vapors are associated with flavorings-related lung disease, a potentially fatal airway disease. The reactive α-dicarbonyl group in diacetyl causes protein damage in vitro. Dicarbonyl/l-xylulose reductase (DCXR) metabolizes diacetyl into acetoin, which lacks this α-dicarbonyl group....

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Publicado no:Am J Pathol
Main Authors: Hubbs, Ann F., Fluharty, Kara L., Edwards, Rebekah J., Barnabei, Jamie L., Grantham, John T., Palmer, Scott M., Kelly, Francine, Sargent, Linda M., Reynolds, Steven H., Mercer, Robert R., Goravanahally, Madhusudan P., Kashon, Michael L., Honaker, John C., Jackson, Mark C., Cumpston, Amy M., Goldsmith, William T., McKinney, Walter, Fedan, Jeffrey S., Battelli, Lori A., Munro, Tiffany, Bucklew-Moyers, Winnie, McKinstry, Kimberly, Schwegler-Berry, Diane, Friend, Sherri, Knepp, Alycia K., Smith, Samantha L., Sriram, Krishnan
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2016
Assuntos:
Regular Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5222965/
https://ncbi.nlm.nih.gov/pubmed/27643531
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2016.07.018
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