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Chromatin Controls DNA Replication Origin Selection, Lagging-Strand Synthesis, and Replication Fork Rates

The integrity of eukaryotic genomes requires rapid and regulated chromatin replication. How this is accomplished is still poorly understood. Using purified yeast replication proteins and fully chromatinized templates, we have reconstituted this process in vitro. We show that chromatin enforces DNA r...

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Dettagli Bibliografici
Pubblicato in:Mol Cell
Autori principali: Kurat, Christoph F., Yeeles, Joseph T.P., Patel, Harshil, Early, Anne, Diffley, John F.X.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Cell Press 2017
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5222724/
https://ncbi.nlm.nih.gov/pubmed/27989438
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2016.11.016
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