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Aqueous urea solution destabilizes Aβ(16–22) oligomers

We use long multiple trajectories generated by molecular dynamics simulations to probe the stability of oligomers of Aβ(16–22) (KLVFFAE) peptides in aqueous urea solution. High concentration of urea promotes the formation of β-strand structures in Aβ(16–22) monomers, whereas in water they adopt larg...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Proc Natl Acad Sci U S A
Prif Awduron: Klimov, D. K., Straub, John E., Thirumalai, D.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 2004
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC522027/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15465917/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0404570101
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