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Charge states rather than propensity for β-structure determine enhanced fibrillogenesis in wild-type Alzheimer's β-amyloid peptide compared to E22Q Dutch mutant

The activity of the Alzheimer's amyloid β-peptide is a sensitive function of the peptide's sequence. Increased fibril elongation rate of the E22Q Dutch mutant of the Alzheimer's amyloid β-peptide relative to that of the wild-type peptide has been observed. The increased activity has b...

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書誌詳細
主要な著者: Massi, Francesca, Klimov, D., Thirumalai, D., Straub, John E.
フォーマット: Artigo
言語:Inglês
出版事項: Cold Spring Harbor Laboratory Press 2002
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2373666/
https://ncbi.nlm.nih.gov/pubmed/12070316
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