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Aqueous urea solution destabilizes Aβ(16–22) oligomers
We use long multiple trajectories generated by molecular dynamics simulations to probe the stability of oligomers of Aβ(16–22) (KLVFFAE) peptides in aqueous urea solution. High concentration of urea promotes the formation of β-strand structures in Aβ(16–22) monomers, whereas in water they adopt larg...
Gorde:
| Argitaratua izan da: | Proc Natl Acad Sci U S A |
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| Egile Nagusiak: | , , |
| Formatua: | Artigo |
| Hizkuntza: | Inglês |
| Argitaratua: |
National Academy of Sciences
2004
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| Gaiak: | |
| Sarrera elektronikoa: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC522027/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15465917/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0404570101 |
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