Humoral immune response to native eukaryotic prion protein correlates with anti-prion protection

Prion diseases are characterized by the deposition of an abnormal form (termed PrP(Sc)) of the cellular prion protein (PrP(C)). Because antibodies to PrP(C) can antagonize deposition of PrP(Sc) in cultured cells and mice, they may be useful for anti-prion therapy. However, induction of protective an...

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Detalhes bibliográficos
Main Authors: Polymenidou, Magdalini, Heppner, Frank L., Pellicioli, Erica C., Urich, Eduard, Miele, Gino, Braun, Nathalie, Wopfner, Franziska, Schätzl, Hermann M., Becher, Burkhard, Aguzzi, Adriano
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2004
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Colloquium
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC521983/
https://ncbi.nlm.nih.gov/pubmed/15292505
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0404772101
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