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Humoral immune response to native eukaryotic prion protein correlates with anti-prion protection

Prion diseases are characterized by the deposition of an abnormal form (termed PrP(Sc)) of the cellular prion protein (PrP(C)). Because antibodies to PrP(C) can antagonize deposition of PrP(Sc) in cultured cells and mice, they may be useful for anti-prion therapy. However, induction of protective an...

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Autors principals: Polymenidou, Magdalini, Heppner, Frank L., Pellicioli, Erica C., Urich, Eduard, Miele, Gino, Braun, Nathalie, Wopfner, Franziska, Schätzl, Hermann M., Becher, Burkhard, Aguzzi, Adriano
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2004
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC521983/
https://ncbi.nlm.nih.gov/pubmed/15292505
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0404772101
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