Truncated Prion Protein and Doppel Are Myelinotoxic in the Absence of Oligodendrocytic PrP(C)

The cellular prion protein PrP(C) confers susceptibility to transmissible spongiform encephalopathies, yet its normal function is unknown. Although PrP(C)-deficient mice develop and live normally, expression of amino proximally truncated PrP(C) (ΔPrP) or of its structural homolog Doppel (Dpl) causes...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Radovanovic, Ivan, Braun, Nathalie, Giger, Olivier T., Mertz, Kirsten, Miele, Gino, Prinz, Marco, Navarro, Beatriz, Aguzzi, Adriano
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2005
Assuntos:
Neurobiology of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6724775/
https://ncbi.nlm.nih.gov/pubmed/15888663
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0328-05.2005
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