Truncated Prion Protein and Doppel Are Myelinotoxic in the Absence of Oligodendrocytic PrP(C)

The cellular prion protein PrP(C) confers susceptibility to transmissible spongiform encephalopathies, yet its normal function is unknown. Although PrP(C)-deficient mice develop and live normally, expression of amino proximally truncated PrP(C) (ΔPrP) or of its structural homolog Doppel (Dpl) causes...

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Dades bibliogràfiques
Publicat a:J Neurosci
Autors principals: Radovanovic, Ivan, Braun, Nathalie, Giger, Olivier T., Mertz, Kirsten, Miele, Gino, Prinz, Marco, Navarro, Beatriz, Aguzzi, Adriano
Format: Artigo
Idioma:Inglês
Publicat: Society for Neuroscience 2005
Matèries:
Neurobiology of Disease
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6724775/
https://ncbi.nlm.nih.gov/pubmed/15888663
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0328-05.2005
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