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Olfactory behavior and physiology are disrupted in prion protein knockout mice

The prion protein PrP(C) is infamous for its role in disease, yet its normal physiological function remains unknown. Here we report a novel behavioral phenotype of PrP(−/−) mice in an odor-guided task. This phenotype is manifest in three PrP knockout lines on different genetic backgrounds, strong ev...

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Detalhes bibliográficos
Main Authors: Le Pichon, Claire E., Valley, Matthew T., Polymenidou, Magdalini, Chesler, Alexander T., Sagdullaev, Botir T., Aguzzi, Adriano, Firestein, Stuart
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2704296/
https://ncbi.nlm.nih.gov/pubmed/19098904
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nn.2238
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