A classical PKA inhibitor increases the oncolytic effect of M1 virus via activation of exchange protein directly activated by cAMP 1

Oncolytic virotherapy is an emerging and promising treatment modality that uses replicating viruses as selective antitumor agents. Here, we report that a classical protein kinase A (PKA) inhibitor, H89, synergizes with oncolytic virus M1 in various cancer cells through activation of Epac1 (exchange...

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Bibliografiske detaljer
Udgivet i:Oncotarget
Main Authors: Li, Kai, Liang, Jiankai, Lin, Yuan, Zhang, Haipeng, Xiao, Xiao, Tan, Yaqian, Cai, Jing, Zhu, Wenbo, Xing, Fan, Hu, Jun, Yan, Guangmei
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2016
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5217030/
https://ncbi.nlm.nih.gov/pubmed/27374176
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.10305
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