Parp1 protects against Aag-dependent alkylation-induced nephrotoxicity in a sex-dependent manner

Nephrotoxicity is a common toxic side-effect of chemotherapeutic alkylating agents. Although the base excision repair (BER) pathway is essential in repairing DNA alkylation damage, under certain conditions the initiation of BER produces toxic repair intermediates that damage healthy tissues. We have...

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Publicado en:Oncotarget
Main Authors: Calvo, Jennifer A., Allocca, Mariacarmela, Fake, Kimberly R., Muthupalani, Sureshkumar, Corrigan, Joshua J., Bronson, Roderick T., Samson, Leona D.
Formato: Artigo
Idioma:Inglês
Publicado: Impact Journals LLC 2016
Assuntos:
Research Paper: Pathology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5216697/
https://ncbi.nlm.nih.gov/pubmed/27391435
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.10440
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