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An Extended Structure–Activity Relationship of Nondioxin-Like PCBs Evaluates and Supports Modeling Predictions and Identifies Picomolar Potency of PCB 202 Towards Ryanodine Receptors
Nondioxin-like polychlorinated biphenyls (NDL PCBs) activate ryanodine-sensitive Ca(2+ )channels (RyRs) and this activation has been associated with neurotoxicity in exposed animals. RyR-active congeners follow a distinct structure–activity relationship and a quantitative structure–activity relation...
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| Pubblicato in: | Toxicol Sci |
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| Autori principali: | , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Oxford University Press
2017
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5216651/ https://ncbi.nlm.nih.gov/pubmed/27655348 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfw189 |
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