An Extended Structure–Activity Relationship of Nondioxin-Like PCBs Evaluates and Supports Modeling Predictions and Identifies Picomolar Potency of PCB 202 Towards Ryanodine Receptors

Nondioxin-like polychlorinated biphenyls (NDL PCBs) activate ryanodine-sensitive Ca(2+ )channels (RyRs) and this activation has been associated with neurotoxicity in exposed animals. RyR-active congeners follow a distinct structure–activity relationship and a quantitative structure–activity relation...

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Bibliografische gegevens
Gepubliceerd in:Toxicol Sci
Hoofdauteurs: Holland, Erika B., Feng, Wei, Zheng, Jing, Dong, Yao, Li, Xueshu, Lehmler, Hans-Joachim, Pessah, Isaac N.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Oxford University Press 2017
Onderwerpen:
Nondioxin-Like PCBs and Ryanodine Receptors
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5216651/
https://ncbi.nlm.nih.gov/pubmed/27655348
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfw189
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