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An Extended Structure–Activity Relationship of Nondioxin-Like PCBs Evaluates and Supports Modeling Predictions and Identifies Picomolar Potency of PCB 202 Towards Ryanodine Receptors

Nondioxin-like polychlorinated biphenyls (NDL PCBs) activate ryanodine-sensitive Ca(2+ )channels (RyRs) and this activation has been associated with neurotoxicity in exposed animals. RyR-active congeners follow a distinct structure–activity relationship and a quantitative structure–activity relation...

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Dades bibliogràfiques
Publicat a:Toxicol Sci
Autors principals: Holland, Erika B., Feng, Wei, Zheng, Jing, Dong, Yao, Li, Xueshu, Lehmler, Hans-Joachim, Pessah, Isaac N.
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2017
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5216651/
https://ncbi.nlm.nih.gov/pubmed/27655348
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfw189
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