PCB 136 Atropselectively Alters Morphometric and Functional Parameters of Neuronal Connectivity in Cultured Rat Hippocampal Neurons via Ryanodine Receptor-Dependent Mechanisms

We recently demonstrated that polychlorinated biphenyl (PCB) congeners with multiple ortho chlorine substitutions sensitize ryanodine receptors (RyRs), and this activity promotes Ca(2+)-dependent dendritic growth in cultured neurons. Many ortho-substituted congeners display axial chirality, and we p...

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Detalhes bibliográficos
Main Authors: Yang, Dongren, Kania-Korwel, Izabela, Ghogha, Atefeh, Chen, Hao, Stamou, Marianna, Bose, Diptiman D., Pessah, Isaac N., Lehmler, Hans-Joachim, Lein, Pamela J.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2014
Assuntos:
Neurotoxicology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4007107/
https://ncbi.nlm.nih.gov/pubmed/24385416
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kft334
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