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Position- and orientation-specific enhancement of topoisomerase I cleavage complexes by triplex DNA structures
Topoisomerase I (Top1) activities are sensitive to various endogenous base modifications, and anticancer drugs including the natural alkaloid camptothecin. Here, we show that triple helix-forming oligonucleotides (TFOs) can enhance Top1-mediated DNA cleavage by affecting either or both the nicking a...
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| Autors principals: | , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Oxford University Press
2004
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC521660/ https://ncbi.nlm.nih.gov/pubmed/15469908 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkh847 |
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