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Enhancement of camptothecin-induced topoisomerase I cleavage complexes by the acetaldehyde adduct N(2)-ethyl-2′-deoxyguanosine
The activity of DNA topoisomerase I (Top1), an enzyme that regulates DNA topology, is impacted by DNA structure alterations and by the anticancer alkaloid camptothecin (CPT). Here, we evaluated the effect of the acetaldehyde-derived DNA adduct, N(2)-ethyl-2′-deoxyguanosine (N(2)-ethyl-dG), on human...
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| Asıl Yazarlar: | , , , , , |
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| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
Oxford University Press
2004
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC524309/ https://ncbi.nlm.nih.gov/pubmed/15498925 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkh902 |
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