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Enhancement of camptothecin-induced topoisomerase I cleavage complexes by the acetaldehyde adduct N(2)-ethyl-2′-deoxyguanosine

The activity of DNA topoisomerase I (Top1), an enzyme that regulates DNA topology, is impacted by DNA structure alterations and by the anticancer alkaloid camptothecin (CPT). Here, we evaluated the effect of the acetaldehyde-derived DNA adduct, N(2)-ethyl-2′-deoxyguanosine (N(2)-ethyl-dG), on human...

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Detalhes bibliográficos
Main Authors: Antony, Smitha, Theruvathu, Jacob A., Brooks, P. J., Lesher, Diem-Thu, Redinbo, Matt, Pommier, Yves
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2004
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC524309/
https://ncbi.nlm.nih.gov/pubmed/15498925
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkh902
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