Mus81-mediated DNA cleavage resolves replication forks stalled by topoisomerase I–DNA complexes

Deoxyribonucleic acid (DNA) topoisomerases are essential for removing the supercoiling that normally builds up ahead of replication forks. The camptothecin (CPT) Top1 (topoisomerase I) inhibitors exert their anticancer activity by reversibly trapping Top1–DNA cleavage complexes (Top1cc’s) and induci...

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Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Regairaz, Marie, Zhang, Yong-Wei, Fu, Haiqing, Agama, Keli K., Tata, Nalini, Agrawal, Surbhi, Aladjem, Mirit I., Pommier, Yves
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: The Rockefeller University Press 2011
Gaiak:
Research Articles
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3257568/
https://ncbi.nlm.nih.gov/pubmed/22123861
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201104003
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