Mus81-mediated DNA cleavage resolves replication forks stalled by topoisomerase I–DNA complexes

Deoxyribonucleic acid (DNA) topoisomerases are essential for removing the supercoiling that normally builds up ahead of replication forks. The camptothecin (CPT) Top1 (topoisomerase I) inhibitors exert their anticancer activity by reversibly trapping Top1–DNA cleavage complexes (Top1cc’s) and induci...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Regairaz, Marie, Zhang, Yong-Wei, Fu, Haiqing, Agama, Keli K., Tata, Nalini, Agrawal, Surbhi, Aladjem, Mirit I., Pommier, Yves
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: The Rockefeller University Press 2011
विषय:
Research Articles
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC3257568/
https://ncbi.nlm.nih.gov/pubmed/22123861
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201104003
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