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Mus81-mediated DNA cleavage resolves replication forks stalled by topoisomerase I–DNA complexes
Deoxyribonucleic acid (DNA) topoisomerases are essential for removing the supercoiling that normally builds up ahead of replication forks. The camptothecin (CPT) Top1 (topoisomerase I) inhibitors exert their anticancer activity by reversibly trapping Top1–DNA cleavage complexes (Top1cc’s) and induci...
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| 主要な著者: | , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
The Rockefeller University Press
2011
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3257568/ https://ncbi.nlm.nih.gov/pubmed/22123861 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201104003 |
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