Mus81-mediated DNA cleavage resolves replication forks stalled by topoisomerase I–DNA complexes

Deoxyribonucleic acid (DNA) topoisomerases are essential for removing the supercoiling that normally builds up ahead of replication forks. The camptothecin (CPT) Top1 (topoisomerase I) inhibitors exert their anticancer activity by reversibly trapping Top1–DNA cleavage complexes (Top1cc’s) and induci...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Main Authors: Regairaz, Marie, Zhang, Yong-Wei, Fu, Haiqing, Agama, Keli K., Tata, Nalini, Agrawal, Surbhi, Aladjem, Mirit I., Pommier, Yves
Format: Artigo
Sprog:Inglês
Udgivet: The Rockefeller University Press 2011
Fag:
Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3257568/
https://ncbi.nlm.nih.gov/pubmed/22123861
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201104003
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker