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Mechanisms controlling replication fork stalling and collapse at topoisomerase 1 cleavage complexes

Topoisomerase 1 cleavage complexes (Top1-ccs) comprise a DNA-protein crosslink and a single-stranded DNA break that can significantly impact the DNA replication machinery (replisome). Consequently, inhibitors that trap Top1-ccs are used extensively in research and clinical settings to generate DNA r...

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Pubblicato in:Mol Cell
Autori principali: Westhorpe, Rose, Roske, Johann J., Yeeles, Joseph T.P.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2024
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7617106/
https://ncbi.nlm.nih.gov/pubmed/39236719
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2024.08.004
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