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Mechanisms controlling replication fork stalling and collapse at topoisomerase 1 cleavage complexes
Topoisomerase 1 cleavage complexes (Top1-ccs) comprise a DNA-protein crosslink and a single-stranded DNA break that can significantly impact the DNA replication machinery (replisome). Consequently, inhibitors that trap Top1-ccs are used extensively in research and clinical settings to generate DNA r...
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| 出版年: | Mol Cell |
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| 主要な著者: | , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2024
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7617106/ https://ncbi.nlm.nih.gov/pubmed/39236719 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2024.08.004 |
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