Chargement en cours...
Position- and orientation-specific enhancement of topoisomerase I cleavage complexes by triplex DNA structures
Topoisomerase I (Top1) activities are sensitive to various endogenous base modifications, and anticancer drugs including the natural alkaloid camptothecin. Here, we show that triple helix-forming oligonucleotides (TFOs) can enhance Top1-mediated DNA cleavage by affecting either or both the nicking a...
Enregistré dans:
| Auteurs principaux: | , , , |
|---|---|
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Oxford University Press
2004
|
| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC521660/ https://ncbi.nlm.nih.gov/pubmed/15469908 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkh847 |
| Tags: |
Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!
|