Immunochemical characterization on pathological oligomers of mutant Cu/Zn-superoxide dismutase in amyotrophic lateral sclerosis

BACKGROUND: Dominant mutations in Cu/Zn-superoxide dismutase (SOD1) gene cause a familial form of amyotrophic lateral sclerosis (SOD1-ALS) with accumulation of misfolded SOD1 proteins as intracellular inclusions in spinal motor neurons. Oligomerization of SOD1 via abnormal disulfide crosslinks has b...

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Enregistré dans:
Détails bibliographiques
Publié dans:Mol Neurodegener
Auteurs principaux: Tokuda, Eiichi, Anzai, Itsuki, Nomura, Takao, Toichi, Keisuke, Watanabe, Masahiko, Ohara, Shinji, Watanabe, Seiji, Yamanaka, Koji, Morisaki, Yuta, Misawa, Hidemi, Furukawa, Yoshiaki
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2017
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5216565/
https://ncbi.nlm.nih.gov/pubmed/28057013
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13024-016-0145-9
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