Histone acetyltransferase activity of MOF is required for adult but not early fetal hematopoiesis in mice

K(lysine) acetyltransferase 8 (KAT8, also known as MOF) mediates the acetylation of histone H4 at lysine 16 (H4K16ac) and is crucial for murine embryogenesis. Lysine acetyltransferases have been shown to regulate various stages of normal hematopoiesis. However, the function of MOF in hematopoietic s...

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Gepubliceerd in:Blood
Hoofdauteurs: Valerio, Daria G., Xu, Haiming, Eisold, Meghan E., Woolthuis, Carolien M., Pandita, Tej K., Armstrong, Scott A.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society of Hematology 2017
Onderwerpen:
Hematopoiesis and Stem Cells
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5216264/
https://ncbi.nlm.nih.gov/pubmed/27827827
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2016-05-714568
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