Ubiquitin Accumulation on Disease Associated Protein Aggregates Is Correlated with Nuclear Ubiquitin Depletion, Histone De-Ubiquitination and Impaired DNA Damage Response

Deposition of ubiquitin conjugates on inclusion bodies composed of protein aggregates is a definitive cytopathological hallmark of neurodegenerative diseases. We show that accumulation of ubiquitin on polyQ IB, associated with Huntington’s disease, is correlated with extensive depletion of nuclear u...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Ben Yehuda, Adi, Risheq, Marwa, Novoplansky, Ofra, Bersuker, Kirill, Kopito, Ron R., Goldberg, Michal, Brandeis, Michael
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5215683/
https://ncbi.nlm.nih.gov/pubmed/28052107
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0169054
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