Heat Shock Response Activation Exacerbates Inclusion Body Formation in a Cellular Model of Huntington Disease

The cellular heat shock response (HSR) protects cells from toxicity associated with defective protein folding, and this pathway is widely viewed as a potential pharmacological target to treat neurodegenerative diseases linked to protein aggregation. Here we show that the HSR is not activated by muta...

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Bibliografiske detaljer
Main Authors: Bersuker, Kirill, Hipp, Mark S., Calamini, Barbara, Morimoto, Richard I., Kopito, Ron R.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2013
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Reports
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3745309/
https://ncbi.nlm.nih.gov/pubmed/23839939
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.C113.481945
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