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Heat Shock Response Activation Exacerbates Inclusion Body Formation in a Cellular Model of Huntington Disease
The cellular heat shock response (HSR) protects cells from toxicity associated with defective protein folding, and this pathway is widely viewed as a potential pharmacological target to treat neurodegenerative diseases linked to protein aggregation. Here we show that the HSR is not activated by muta...
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| Главные авторы: | , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
American Society for Biochemistry and Molecular Biology
2013
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3745309/ https://ncbi.nlm.nih.gov/pubmed/23839939 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.C113.481945 |
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