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Human tau increases amyloid β plaque size but not amyloid β‐mediated synapse loss in a novel mouse model of Alzheimer's disease

Alzheimer's disease is characterized by the presence of aggregates of amyloid beta (Aβ) in senile plaques and tau in neurofibrillary tangles, as well as marked neuron and synapse loss. Of these pathological changes, synapse loss correlates most strongly with cognitive decline. Synapse loss occu...

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Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Τόπος έκδοσης:Eur J Neurosci
Κύριοι συγγραφείς: Jackson, Rosemary J., Rudinskiy, Nikita, Herrmann, Abigail G., Croft, Shaun, Kim, JeeSoo Monica, Petrova, Veselina, Ramos‐Rodriguez, Juan Jose, Pitstick, Rose, Wegmann, Susanne, Garcia‐Alloza, Monica, Carlson, George A., Hyman, Bradley T., Spires‐Jones, Tara L.
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: John Wiley and Sons Inc. 2016
Θέματα:
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5215483/
https://ncbi.nlm.nih.gov/pubmed/27748574
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/ejn.13442
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