Oxidized CaMKII promotes asthma through the activation of mast cells

Oxidation of calmodulin-dependent protein kinase II (ox-CaMKII) by ROS has been associated with asthma. However, the contribution of ox-CaMKII to the development of asthma remains to be fully characterized. Here, we tested the effect of ox-CaMKII on IgE-mediated mast cell activation in an allergen-i...

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Publicat a:JCI Insight
Autors principals: Qu, Jingjing, Do, Danh C., Zhou, Yufeng, Luczak, Elizabeth, Mitzner, Wayne, Anderson, Mark E., Gao, Peisong
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2017
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5214090/
https://ncbi.nlm.nih.gov/pubmed/28097237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.90139
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