CaMKII Is Essential for the Proasthmatic Effects of Oxidation

Increased reactive oxygen species (ROS) contribute to asthma, but little is known about the molecular mechanisms connecting increased ROS with characteristic features of asthma. We show that enhanced oxidative activation of the Ca(2+)/calmodulin-dependent protein kinase (ox-CaMKII) in bronchial epit...

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Publicado no:Sci Transl Med
Main Authors: Sanders, Philip N., Koval, Olha M., Jaffer, Omar A., Prasad, Anand M., Businga, Thomas R., Scott, Jason A., Hayden, Patrick J., Luczak, Elizabeth D., Dickey, David D., Allamargot, Chantal, Olivier, Alicia K., Meyerholz, David K., Robison, Alfred J., Winder, Danny G., Blackwell, Timothy S., Dworski, Ryszard, Sammut, David, Wagner, Brett A., Buettner, Garry R., Pope, Robert M., Miller, Francis J., Dibbern, Megan E., Haitchi, Hans Michael, Mohler, Peter J., Howarth, Peter H., Zabner, Joseph, Kline, Joel N., Grumbach, Isabella M., Anderson, Mark E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4331168/
https://ncbi.nlm.nih.gov/pubmed/23884469
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.3006135
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