CaMKII Is Essential for the Proasthmatic Effects of Oxidation

Increased reactive oxygen species (ROS) contribute to asthma, but little is known about the molecular mechanisms connecting increased ROS with characteristic features of asthma. We show that enhanced oxidative activation of the Ca(2+)/calmodulin-dependent protein kinase (ox-CaMKII) in bronchial epit...

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Vydáno v:Sci Transl Med
Hlavní autoři: Sanders, Philip N., Koval, Olha M., Jaffer, Omar A., Prasad, Anand M., Businga, Thomas R., Scott, Jason A., Hayden, Patrick J., Luczak, Elizabeth D., Dickey, David D., Allamargot, Chantal, Olivier, Alicia K., Meyerholz, David K., Robison, Alfred J., Winder, Danny G., Blackwell, Timothy S., Dworski, Ryszard, Sammut, David, Wagner, Brett A., Buettner, Garry R., Pope, Robert M., Miller, Francis J., Dibbern, Megan E., Haitchi, Hans Michael, Mohler, Peter J., Howarth, Peter H., Zabner, Joseph, Kline, Joel N., Grumbach, Isabella M., Anderson, Mark E.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2013
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4331168/
https://ncbi.nlm.nih.gov/pubmed/23884469
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.3006135
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