CaMKII Is Essential for the Proasthmatic Effects of Oxidation

Increased reactive oxygen species (ROS) contribute to asthma, but little is known about the molecular mechanisms connecting increased ROS with characteristic features of asthma. We show that enhanced oxidative activation of the Ca(2+)/calmodulin-dependent protein kinase (ox-CaMKII) in bronchial epit...

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Publicat a:Sci Transl Med
Autors principals: Sanders, Philip N., Koval, Olha M., Jaffer, Omar A., Prasad, Anand M., Businga, Thomas R., Scott, Jason A., Hayden, Patrick J., Luczak, Elizabeth D., Dickey, David D., Allamargot, Chantal, Olivier, Alicia K., Meyerholz, David K., Robison, Alfred J., Winder, Danny G., Blackwell, Timothy S., Dworski, Ryszard, Sammut, David, Wagner, Brett A., Buettner, Garry R., Pope, Robert M., Miller, Francis J., Dibbern, Megan E., Haitchi, Hans Michael, Mohler, Peter J., Howarth, Peter H., Zabner, Joseph, Kline, Joel N., Grumbach, Isabella M., Anderson, Mark E.
Format: Artigo
Idioma:Inglês
Publicat: 2013
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4331168/
https://ncbi.nlm.nih.gov/pubmed/23884469
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.3006135
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