Oxidized CaMKII Triggers Atrial Fibrillation

BACKGROUND: Atrial fibrillation is a growing public health problem without adequate therapies. Angiotensin II (Ang II) and reactive oxygen species (ROS) are validated risk factors for atrial fibrillation (AF) in patients, but the molecular pathway(s) connecting ROS and AF is unknown. The Ca(2+)/calm...

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Main Authors: Purohit, Anil, Rokita, Adam G., Guan, Xiaoqun, Chen, Biyi, Koval, Olha M., Voigt, Niels, Neef, Stefan, Sowa, Thomas, Gao, Zhan, Luczak, Elizabeth D., Stefansdottir, Hrafnhildur, Behunin, Andrew C., Li, Na, El-Accaoui, Ramzi N., Yang, Baoli, Swaminathan, Paari Dominic, Weiss, Robert M., Wehrens, Xander H.T., Song, Long-Sheng, Dobrev, Dobromir, Maier, Lars S., Anderson, Mark E.
Format: Artigo
Language:Inglês
Published: 2013
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3876034/
https://ncbi.nlm.nih.gov/pubmed/24030498
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.113.003313
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