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DJ-1 Is a Redox-Dependent Molecular Chaperone That Inhibits α-Synuclein Aggregate Formation

Parkinson's disease (PD) pathology is characterized by the degeneration of midbrain dopamine neurons (DNs) ultimately leading to a progressive movement disorder in patients. The etiology of DN loss in sporadic PD is unknown, although it is hypothesized that aberrant protein aggregation and cell...

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Autors principals: Shendelman, Shoshana, Jonason, Alan, Martinat, Cecile, Leete, Thomas, Abeliovich, Asa
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2004
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC521177/
https://ncbi.nlm.nih.gov/pubmed/15502874
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.0020362
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