Sensitivity to Oxidative Stress in DJ-1-Deficient Dopamine Neurons: An ES- Derived Cell Model of Primary Parkinsonism

The hallmark of Parkinson's disease (PD) is the selective loss of dopamine neurons in the ventral midbrain. Although the cause of neurodegeneration in PD is unknown, a Mendelian inheritance pattern is observed in rare cases, indicating a genetic factor. Furthermore, pathological analyses of PD...

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Autors principals: Martinat, Cecile, Shendelman, Shoshana, Jonason, Alan, Leete, Thomas, Beal, M. Flint, Yang, Lichuan, Floss, Thomas, Abeliovich, Asa
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2004
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC521171/
https://ncbi.nlm.nih.gov/pubmed/15502868
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.0020327
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