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Sensitivity to Oxidative Stress in DJ-1-Deficient Dopamine Neurons: An ES- Derived Cell Model of Primary Parkinsonism

The hallmark of Parkinson's disease (PD) is the selective loss of dopamine neurons in the ventral midbrain. Although the cause of neurodegeneration in PD is unknown, a Mendelian inheritance pattern is observed in rare cases, indicating a genetic factor. Furthermore, pathological analyses of PD...

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Detalhes bibliográficos
Main Authors: Martinat, Cecile, Shendelman, Shoshana, Jonason, Alan, Leete, Thomas, Beal, M. Flint, Yang, Lichuan, Floss, Thomas, Abeliovich, Asa
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2004
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC521171/
https://ncbi.nlm.nih.gov/pubmed/15502868
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.0020327
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