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Regional deficiencies in chaperone-mediated autophagy underlie α-synuclein aggregation and neurodegeneration

In neurodegenerative diseases, it remains unclear why certain brain regions are selectively vulnerable to protein aggregation. In transgenic mice expressing human A53T α-synuclein, the brainstem and spinal cord develop the most prominent α-synuclein inclusions which correlate with age-dependent moto...

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Hlavní autoři: Malkus, Kristen A., Ischiropoulos, Harry
Médium: Artigo
Jazyk:Inglês
Vydáno: 2012
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3352979/
https://ncbi.nlm.nih.gov/pubmed/22426402
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2012.03.017
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