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Regional deficiencies in chaperone-mediated autophagy underlie α-synuclein aggregation and neurodegeneration
In neurodegenerative diseases, it remains unclear why certain brain regions are selectively vulnerable to protein aggregation. In transgenic mice expressing human A53T α-synuclein, the brainstem and spinal cord develop the most prominent α-synuclein inclusions which correlate with age-dependent moto...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2012
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| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3352979/ https://ncbi.nlm.nih.gov/pubmed/22426402 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2012.03.017 |
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