MiR‐590 Promotes Transdifferentiation of Porcine and Human Fibroblasts Toward a Cardiomyocyte‐Like Fate by Directly Repressing Specificity Protein 1

BACKGROUND: Reprogramming of cardiac fibroblasts into induced cardiomyocyte‐like cells represents a promising potential new therapy for treating heart disease, inducing significant improvements in postinfarct ventricular function in rodent models. Because reprogramming factors effective in transdiff...

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Detalhes bibliográficos
Publicado no:J Am Heart Assoc
Main Authors: Singh, Vivek P., Mathison, Megumi, Patel, Vivekkumar, Sanagasetti, Deepthi, Gibson, Brian W., Yang, Jianchang, Rosengart, Todd K.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2016
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5210349/
https://ncbi.nlm.nih.gov/pubmed/27930352
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.116.003922
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