Adults with Philadelphia chromosome–like acute lymphoblastic leukemia frequently have IGH-CRLF2 and JAK2 mutations, persistence of minimal residual disease and poor prognosis

Philadelphia-like B-cell precursor acute lymphoblastic leukemia (Ph-like ALL) is characterized by distinct genetic alterations and inferior prognosis in children and younger adults. The purpose of this study was a genetic and clinical characterization of Ph-like ALL in adults. Twenty-six (13%) of 20...

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Publicado en:Haematologica
Main Authors: Herold, Tobias, Schneider, Stephanie, Metzeler, Klaus H., Neumann, Martin, Hartmann, Luise, Roberts, Kathryn G., Konstandin, Nikola P., Greif, Philipp A., Bräundl, Kathrin, Ksienzyk, Bianka, Huk, Natalia, Schneider, Irene, Zellmeier, Evelyn, Jurinovic, Vindi, Mansmann, Ulrich, Hiddemann, Wolfgang, Mullighan, Charles G., Bohlander, Stefan K., Spiekermann, Karsten, Hoelzer, Dieter, Brüggemann, Monika, Baldus, Claudia D., Dreyling, Martin, Gökbuget, Nicola
Formato: Artigo
Idioma:Inglês
Publicado: Ferrata Storti Foundation 2017
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Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5210243/
https://ncbi.nlm.nih.gov/pubmed/27561722
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2015.136366
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