Implications of the differing roles of the β1 and β3 transmembrane and cytoplasmic domains for integrin function

Integrins are transmembrane receptors composed of α and β subunits. Although most integrins contain β1, canonical activation mechanisms are based on studies of the platelet integrin, αIIbβ3. Its inactive conformation is characterized by the association of the αIIb transmembrane and cytosolic domain...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Lu, Zhenwei, Mathew, Sijo, Chen, Jiang, Hadziselimovic, Arina, Palamuttam, Riya, Hudson, Billy G, Fässler, Reinhard, Pozzi, Ambra, Sanders, Charles R, Zent, Roy
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2016
Assuntos:
Biochemistry
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5207772/
https://ncbi.nlm.nih.gov/pubmed/27929375
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.18633
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